Publications

Les articles ci-dessous ont été publiés dans des revues scientifiques internationales. Ils sont le fruit des travaux réalisés par l’équipe de l’Unité de recherche sur la schizophrénie (URS) et sont disponibles uniquement en anglais. Certains articles sont en libre accès, d’autres requièrent une souscription à la revue en question – tous droits réservés. Pour toute question, merci de vous adresser à cmarich@alamay.net.

Pour consulter la liste complète des publications de la Prof. Kim Do Cuénod (directrice de l’URS), merci de cliquer ici.

Molecular Psychiatry
MMP9/RAGE pathway overactivation mediates redox dysregulation and neuroinflammation, leading to inhibitory/excitatory imbalance: a reverse translation study in schizophrenia patients
2019 – Epub ahead of print
© 2019 the Author(s)

Proceedings of the National Academy of Sciences of the United States of America
Redox dysregulation as a link between childhood trauma and psychopathological and neurocognitive profile in patients with early psychosis
2018 – Volume 115 – Pages 12495-12500
© 2018 the Author(s)

Translational Psychiatry
N-acetylcysteine add-on treatment leads to an improvement of fornix white matter integrity in early psychosis: a double-blind randomized placebo-controlled trial
2018 – Volume 8 – Article 220
© The Author(s) 2018

Schizophrenia Research
Patients participating to neurobiological research in early psychosis: A selected subgroup?
2018 – Volume 201 – Pages 249-253
© 2018 Elsevier B.V. All rights reserved

Early Intervention in Psychiatry
Frontal cortical thickness correlates positively with impulsivity in early psychosis male patients
2018 – Epub ahead of print
© 2018 Wiley Publishing Asia Pty Ltd

Translational Psychiatry
Networks of blood proteins in the neuroimmunology of schizophrenia
2018 – Volume 8 – Article 112
© The Author(s) 2018

Schizophrenia Bulletin
N-acetylcysteine in a double-blind randomized placebo-controlled trial: toward biomarker-guided treatment in early psychosis
2018 – Volume 44 – Pages 317-327
© The Author(s) 2017

European Psychiatry
Impulsivity in early psychosis: A complex link with violent behaviour and a target for intervention
2018 – Volume 49 – Pages 30-36
© 2017 Elsevier Masson SAS

Neurobiology of Disease
A lack of GluN2A-containing NMDA receptors confers a vulnerability to redox dysregulation: consequences on parvalbumin interneurons, and their perineuronal nets
2018 – Volume 109 – Pages 64-75
© 2017 Published by Elsevier Inc.

Schizophrenia Research
Treatment in early psychosis with N-Acetyl-Cysteine for 6 months improves low-level auditory processing: pilot study
2018 – Volume 191 – Pages 80-86
© 2017 Elsevier B.V. All rights reserved

Psychopharmacology
Cannabis use in early psychosis is associated with reduced glutamate levels in the prefrontal cortex
2018 – Volume 235 – Pages 13-22
© Springer-Verlag GmbH Germany 2017

Molecular Psychiatry
The thalamic reticular nucleus in schizophrenia and bipolar disorder: role of parvalbumin-expressing neuron networks and oxidative stress
2018 – Volume 23 – Pages 2057-2065
© The Author(s) 2017

Schizophrenia Research
The coupling of low-level auditory dysfunction and oxidative stress in psychosis patients
2017 – Volume 190 – Pages 52-59
© 2017 Elsevier B.V. All rights reserved

npj Schizophrenia
Implication of the glutamate-cystine antiporter xCT in schizophrenia cases linked to impaired GSH synthesis
2017 – 3:31 – doi:10.1038/s41537-017-0035-3 [online-only]
© The Author(s) 2017

Journal of Neurochemistry
Social isolation stress and chronic glutathione deficiency have a common effect on the glutamine-to-glutamate ratio and myo-inositol concentration in the mouse frontal cortex
2017 – Volume 142 – Pages 767-775
© 2017 International Society for Neurochemistry

Molecular Psychiatry
Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia
2017 – Volume 22 – Pages 936-943
© The Author(s) 2017

Schizophrenia Bulletin
Mild depressive symptoms mediate the impact of childhood trauma on long-term functional outcome in early psychosis patients
2017 – Volume 43 – Pages 1027-1035
© The Author 2016

Molecular Psychiatry
Nrf2-dependent persistent oxidative stress results in stress-induced vulnerability to depression
2017 – Volume 22 – Pages 1701-1713
© The Author(s) 2016

Journal of Neuroinflammation
Tollip, en early regulator of the acute inflammatory response in the substantia nigra
2016 – Volume 13 – Article 303
© The Author(s) 2016

Translational Psychiatry
Impaired fornix-hippocampus integrity is linked to peripheral glutathione peroxidase in early psychosis
2016 – Volume 6 – Article 859
© The Author(s) 2016

Journal of Clinical Psychiatry
Age at the time of exposure to trauma modulates the psychopathological profile in patients with early psychosis
2016 – Volume 77 – Pages e612-e618
© Copyright 2016 Physicians Postgraduate Press, Inc.

Schizophrenia Bulletin
Genetic polymorphism associated prefrontal glutathione and its coupling with brain glutamate and peripheral redox status in early psychosis
2016 – Volume 42 – Pages 1185-1196
© The Author 2016

Schizophrenia Research
Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: a « central hub » in schizophrenia pathophysiology?
2016 – Volume 176 – Pages 41-51
© 2014 Elsevier B.V.

Frontiers in Physiology
Glutamate cysteine ligase-modulatory subunit knockout mouse shows normal insulin sensitivity but reduced liver glycogen storage
2016 – Volume 7 – Article 142
© 2016 Lavoie, Steullet, Kulak, Preitner, Do and Magistretti

Nature Reviews Neuroscience
Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis
2016 – Volume 17 – Pages 125-134
© 2016 Macmillan Publishers Limited

PLoS ONE
Decreased brain levels of vitamin B12 in aging, autism and schizophrenia
2016 – Volume 11 – e0146797
© 2016 Zhang et al.

International Journal of Neuropsychopharmacology
Glutathione deficit affects the integrity and function of the fimbria/fornix and anterior commissure in mice: relevance for schizophrenia
2016 – Volume 19 – Pages 1-11
© The Author 2015

Handbook of Behavioral Neuroscience
Modeling the psychopathological dimensions of schizophrenia – From molecules to behavior
2015 – Volume 23 – Chapter 28 – Pages 481-500
© 2016 Elsevier B.V.

Psychological Medicine
Childhood sexual and physical abuse: age at exposure modulates impact on functional outcome in early psychosis patients
2015 – Volume 45 – Pages 2727-2736
© Cambridge University Press 2015

Psychiatry Research
Benefits of adjunctive N-acetylcysteine in a sub-group of clozapine-treated individuals diagnosed with schizophrenia
2015 – Volume 230 – Pages 982-983
© 2015 Elsevier Ireland Ltd.

Neuroscience and Biobehavioral Reviews
Inflammation in schizophrenia: a question of balance
2015 – Volume 55 – Pages 612-626
© 2015 Elsevier Ltd.

Biological Psychiatry
Prolonged period of cortical plasticity upon redox dysregulation in fast-spiking interneurons
2015 – Volume 78 – Pages 396-402
© 2015 Society of Biological Psychiatry

Schizophrenia Bulletin
Targeting oxidative stress and aberrant critical period plasticity in the developmental trajectory to schizophrenia
2015 – Volume 41 – Pages 835-846
© The Author 2015

Molecular Psychiatry
Glutathione deficit impairs myelin maturation: relevance for white matter integrity in schizophrenia patients
2015 – Volume 20 – Pages 827-838
© Macmillan Publishers Limited

Human Brain Mapping
Characterizing the connectome in schizophrenia with diffusion spectrum imaging
2015 – Volume 36 – Pages 354-366
© 2014 Wiley Periodicals, Inc.

Molecular Psychiatry
Cortical fast-spiking parvalbumin interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts8, Adamts15 and Neprilysin
2015 – Volume 20 – Pages 154-161
© 2014 Macmillan Publishers Limited

Frontiers in Cellular Neuroscience
Fast oscillatory activity in the anterior cingular cortex: dopaminergic modulation and effect of perineuronal net loss
2014 – Volume 8 – Article 244
© 2014 Steullet, Cabungcal, Cuénod and Do

Schizophrenia Bulletin
Oxidative/Nitrosative stress in psychiatric disorders: are we there yet?
2014 – Volume 40 – Pages 960-962
© The Author 2014

Neurobiology of Aging
Longitudinal neurochemical modifications in the aging mouse brain measured in vivo by (1)H magnetic resonance spectroscopy
2014 – Volume 35 – Pages 1660-1668
© 2014 Elsevier Inc.

Neuron
Juvenile antioxidant treatment prevents adult deficits in a developmental model of schizophrenia
2014 – Volume 83 – Pages 1073-1084
© 2014 Elsevier Inc.

Schizophrenia Bulletin
Impaired metabolic reactivity to oxidative stress in early psychosis patients
2014 – Volume 40 – Pages 973-983
©The Author 2014

Early Intervention in Psychiatry
Treatment and early intervention in psychosis program (TIPP-Lausanne): implementation of an early intervention programme for psychosis in Switzerland
2013 – Volume 7 – Pages 322-328
© Wiley Publishing Asia Pty Ltd

Proceedings of the National Academy of Sciences of the United States of America
Perineuronal nets protect fast-spiking interneurons against oxidative stress
2013 – Volume 110 – Pages 9130-9135
© The National Academy of Sciences of the USA

Biological Psychiatry
Early-life insults impair parvalbumin interneurons via oxidative stress: reversal by N-Acetylcysteine
2013 -Volume 73 – Pages 574-582
© 2013 Society of Biological Psychiatry

Antioxidants & Redox Signaling
Redox dysregulation in the pathophysiology of schizophrenia and bipolar disorder: insights from animal models
2013 – Volume 18 – Pages 1428-1443
© Mary Ann Liebert, Inc.

Psychiatry Research: Neuroimaging
High b-value diffusion-weighted imaging: a sensitive method to reveal white matter differences in schizophrenia
2012 – Volume 201 – Pages 144-151
© 2011 Elsevier Ireland Ltd. All rights reserved

PLoS ONE
Glutathione precursor, N-acetyl-cysteine, modulates EEG synchronization in schizophrenia patients: a double-blind randomized placebo-controlled trial
2012 – Volume 7 – e29341
© Carmeli et al.

Behavioural Brain Research
Behavioral phenotyping of glutathione-deficient mice: relevance to schizophrenia and bipolar disorder
2012 – Volume 226 – Pages 563-570
© 2011 Elsevier B.V. All rights reserved

Biological Psychiatry
N-acetylcysteine normalizes neurochemical changes in the glutathione-deficient schizophrenia mouse model during development
2012 – Volume 71 – Pages 1006-1014
© 2012 Society of Biological Psychiatry

PLoS ONE
Altered glycogen metabolism in cultured astrocytes from mice with chronic glutathione deficit; relevance for neuroenergetics in schizophrenia
2011 – Volume 6 – e22875
© 2011 Lavoie et al.

Antioxidants & Redox Signaling
Genetic dysregulation of glutathione synthesis predicts alteration of plasma thiol redox status in schizophrenia
2011 – Volume 15 – Pages 2003-2010
© Mary Ann Liebert, Inc.

Free Radical Biology & Medicine
Interaction of GAG trinucleotide repeat and C – 129 T polymorphisms impairs expression of the glutamate-cysteine ligase catalytic subunit gene
2011 – Volume 50 – Pages 617-623
© Elsevier Inc. All rights reserved

Journal of Neurochemistry
Neurochemical profile of the developing mouse cortex determined by in vivo 1 H NMR spectroscopy at 14.1 T and the effect of recurrent anaesthesia
2010 – Volume 115 – Pages 1466-1477
© 2010 International Society for Neurochemistry

The Journal of Neuroscience
Redox dysregulation affects the ventral but not dorsal hippocampus: impairment of parvalbumin neurons, gamma oscillations, and related behaviors
2010 – Volume 30(7) – Pages 2547-2558
© 2010 The Authors

Current Opinion in Neurobiology
Redox dysregulation, neurodevelopment, and schizophrenia
2009 – Volume 19 – Pages 1-11
© 2009 Elsevier Ltd.

Journal of Neurochemistry
Curcumin, quercetin, and tBHQ modulate glutathione levels in astrocytes and neurons: importance of the glutamate cysteine ligase modifier subunit
2009 – Volume 108 – Pages 1410-1422
© 2009 International Society for Neurochemistry

Biological Psychiatry
N-Acetyl Cysteine as a glutathione precursor for schizophrenia – A double-blind, randomized, placebo-controlled trial
2008 – Volume 64 – Pages 361-368
© 2008 Society of Biological Psychiatry

Neuropsychopharmacology
Glutathione precursor, N-Acetyl Cysteine, improves mismatch negativity in schizophrenia patients
2008 – Volume 33 – Pages 2187-2199
© 2008 Nature Publishing Group

Proceedings of the National Academy of Sciences of the United States of America
Impaired glutathione synthesis in schizophrenia: convergent genetic and functional evidence
2007 – Volume 104 – No 42 – Pages 16621-16626
© 2007 The National Academy of Sciences of the USA

The American Journal of Human Genetics
Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene
2006 – Volume 79 – Pages 586-592
© 2006 The American Society of Human Genetics